Steroids are hormones that occur naturally in the body. Steroid medicines are man-made and are similar to the natural hormones made in the body. An acute exacerbation is more commonly known as a 'flare-up'. An acute exacerbation of chronic obstructive pulmonary disease (COPD) is a sudden worsening of COPD symptoms https://nativ.media:443/wiki/index.php?tipbeard683