This methylation profile is previously acquired within the MBL stage3 and stays comparatively secure over time. On the other hand, some CLL have intratumor variability in certain regions, which can alter the expression of quite a few genes and facilitate tumor evolution.71 Of note, this variability is larger in U-CLL https://felixsixkz.blog5.net/75696910/about-link-alternatif-mbl77