Remark: Barbiturates might enhance adverse effects, together with respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates boost metabolism and reduce blood concentrations of TCAs. pentobarbital will minimize the level or impact of disopyramide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Not known. CYP3A4 indu... https://heinzv304xod7.pennywiki.com/user